Therapeutic antibodiesare artificial substances that can bind to specific proteins on the surfaces of cells. Usually such substances are applied to treat cancer or autoimmune diseases due to their high level of binding specificity. In some circumstances, the binding specificity of therapeutic antibodies is used to precisely deliver drugs or drug-activating enzymes to precise cellular locations. In other circumstances, the proteins are used to inhabit binding sites on a given cell, reducing the effects of the overactive immune responses that characterize autoimmune diseases.
Many different useful therapeutic antibodies have been synthesized, which result in a large market for such substances. Most therapeutic antibodies are monoclonal antibodies that are routinely used in biochemistry, molecular biology and medical research, meaning that they are antibodies produced by clones of a single immune cell, for example,IL6and CD4. Each monoclonal antibody is only able to bind to a single antigen. Both of these properties are highly important when such antibodies are being used for therapeutic purposes. A heterogeneous mix of antibodies that binds to a nonspecific variety of antigens has little therapeutic value as specific binding and precise drug delivery are the two traits that make therapeutic antibodies effective. Monoclonal antibodies can be made to specifically target almost any substance; this capability is highly useful for detection and for targeted drug delivery.
There are many different types of therapeutic antibodies that can be produced in many different ways. Most antibodies are produced within mice and injected into humans in order to fight disease. Rejection, however, is a major problem in antibody production as the human immune system attacks nonhuman antibodies. The human immune system actually produces human anti-mouse antibodies, or HAMAs, in order to confront the perceived threat posed by the mouse antibodies. To deal with this problem, scientists use chimeric antibodies, which are combinations of both human and mouse antibodies, or fully human antibodies, which are produced within the human body to avoid immune response problems.
Important advances have been made over the past decade. These developments, along with a greater understanding of the immunomodulatory properties of antibodies, have paved the way for the next generation of new and improved antibody-based drugs for the treatment of human diseases. Creative Biomart is among one of those contributors. It gains reputation with its trusted products and perfect price. In addition, Creative Biomart provides full services, such as Protein Expression (Bacterial Expression Systems (E. coli / Bacillus), Yeast Expression Systems (P pastoris / S cerevisiae), Baculovirus-insect Cell Expression Systems, Mammalian Expression Systems (CHO / 293)), Membrane Protein (Custom Membrane Protein Production, Cell Line Development and Membrane Preparation, Custom Lipoparticle Containing Membrane Protein, Lipid-based Protein Immobilization), PEGylation Services, Directed Evolution, Protein Engineering, Mutagenesis Services (Site-Directed Mutagenesis, Site-Saturation Mutagenesis, Controlled Randomization Service), Protein Microarray , Custom cDNA clone etc. There are also experts in Creative Biomart who are continually improving and advancing the technology and products/services for the research demands.
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